VitMode
Backed by 611+ scientific studies

Health knowledge you can actually trust

The most thorough evidence-based knowledge base on biohacking, longevity and lifestyle medicine. Well-sourced articles — no marketing hype.

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The knowledge base grows every month

Jan 25 → Nov 26

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Three principles we apply to every knowledge base entry — no exceptions.

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Transparent evidence rating

Every entry has an Evidence Score of 1–5 and a documented methodology — you can see exactly what the rating is based on.

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Editorial verification

Content is prepared by the VitMode editorial team from primary sources, and cited PubMed records are automatically verified against the NCBI database.

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Sources always disclosed

Every claim links to the original scientific publication so you can verify it yourself.

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News

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Fresh articles from the VitMode editorial team.

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Mężczyzna przyjmuje tabletkę, popijając ją szklanką

Ibuprofen and Alcohol: Can You Mix Them and What Is the Risk?

Ibuprofen and alcohol do not trigger a dangerous chemical reaction, but both irritate the stomach lining and both can burden the kidneys. The best available data come from a case-control study of 1,224 people with upper gastrointestinal bleeding: regular ibuprofen use was linked to a risk about 2.7 times higher, while occasional use showed no significant increase. We explain what this means for someone who fancies a glass of wine and a tablet for a headache, who should avoid the combination altogether, and what science does not yet know.

12 min

November 3, 2026

Zestaw tabletek i kapsułek w blistrach na czerwonym tle

Paracetamol (Acetaminophen): Maximum Daily Dose, the Liver and Alcohol

Paracetamol is often regarded as a safe drug, but the line between a therapeutic and a toxic dose is narrower than for many other popular medicines. According to the NIH information page, the maximum dose for adults from all sources combined is 4,000 mg a day, and in a randomised trial in healthy adults taking exactly 4 g a day, ALT activity exceeded three times the upper limit of normal in 31-44% of people. We explain the mechanism of liver injury (NAPQI and glutathione), what is really known about alcohol, why a staggered overdose is dangerous, and in which combination products paracetamol hides.

13 min

November 3, 2026

Puste blistry po lekach na drewnianej powierzchni

NSAIDs, Blood Pressure and the Kidneys: Who Should Be Careful

Nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen, diclofenac) can raise blood pressure by about 5 mmHg on average and weaken blood pressure medicines, and combined with a diuretic and an ACE inhibitor or sartan they form the so-called triple whammy for the kidneys. We present data from a meta-analysis of randomised trials, from a 4-month trial with ambulatory blood pressure monitoring, from a large population study and from a Cochrane review of drugs applied to the skin. We also explain why paracetamol is not entirely neutral for blood pressure either, who should be most careful and what to do instead of reaching for a tablet.

13 min

November 3, 2026

Knowledge base

Browse by category

Popular supplements, vitamins, adaptogens, functional mushrooms, diets and more — one place, vetted sources.

Full knowledge base

Suplementy, witaminy i minerały — od kreatyny i kolagenu po witaminę D3 i magnez — z dawkowaniem i suplementacją opartą na dowodach.

Miarka proszku kreatyny monohydrat

Creatine

One of the most thoroughly studied supplements in the world — supports strength, muscle mass and, according to newer research, cognitive function.

SuplementyStrong evidence
Miska świeżych jagód bogatych w antyoksydanty

Collagen

Collagen peptides are often used as a supportive measure for skin elasticity and joint comfort — the evidence is promising but still limited.

SuplementyModerate evidence
Światło słoneczne padające na skórę

Vitamin D3

Functionally it acts like a steroid hormone — deficiencies are widespread in Poland, especially during autumn and winter.

SuplementyStrong evidence
Kapsułki i tabletki suplementów na marmurowym blacie

Magnesium

A cofactor for more than 300 enzymatic reactions — essential for neuromuscular function, sleep and energy metabolism.

SuplementyStrong evidence
Zbliżenie na różnorodne suplementy diety, witaminy i probiotyki

Zinc

A trace element essential for the work of over 300 enzymes in the body — its deficiency, more common than widely believed, affects immunity, wound healing, and hormone balance.

SuplementyModerate evidence
Kapsułki oleju rybiego wysypujące się z pojemnika obok niebieskiej butelki

Omega-3 Fatty Acids

The polyunsaturated fatty acids EPA and DHA have one of the strongest evidence bases among cardiometabolic supplements — but the effect depends heavily on baseline blood levels, not just the dose on the label.

SuplementyStrong evidence
Ampułki z lekiem na białej powierzchni

Vitamin B12

The only vitamin the body can store in the liver for years — yet its deficiency is often mistaken for dementia, depression or plain fatigue, because neurological changes can precede any abnormality in a standard blood count by years.

SuplementyStrong evidence
Buteleczka serum do pielęgnacji skóry obok zielonej rośliny

Niacinamide (Nicotinamide)

A rare ingredient that genuinely spans two different worlds: as vitamin B3 taken orally it prevents pellagra and serves as an NAD+ precursor, while as a skincare ingredient it regulates sebum, strengthens the skin barrier and brightens discoloration — with real, if differently weighted, clinical evidence on both sides.

SuplementyStrong evidence
Detaliczne zbliżenie na uśmiechnięte, białe zęby

Xylitol and Dental Health

A sweetener that cavity-causing bacteria can't effectively ferment the way they ferment sugar — unlike sucrose, xylitol may limit their growth and adhesion to enamel, a mechanism studied for decades as a practical element of dental caries prevention, though popular articles often overstate how strong and unambiguous that evidence actually is.

SuplementyModerate evidence

Editorial team

Meet our editorial team

Content is prepared by VitMode topic-based editorial desks from primary sources.

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VM

Redakcja VitMode — Badania i biomarkery

Editorial team

VitMode Editorial — Lab Tests and Biomarkers is the VitMode editorial team responsible for: laboratory tests, interpreting results and ageing biomarkers. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

183 publications

VM

Redakcja VitMode — Żywienie, suplementy i trening

Editorial team

VitMode Editorial — Nutrition, Supplements and Training is the VitMode editorial team responsible for: nutrition, supplements, interactions and training. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

133 publications

VM

Redakcja VitMode — Hormony i endokrynologia

Editorial team

VitMode Editorial — Hormones and Endocrinology is the VitMode editorial team responsible for: hormones, testosterone therapy, the thyroid and metabolism. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

199 publications

VM

Redakcja VitMode — Sen i neurobiologia

Editorial team

VitMode Editorial — Sleep and Neurobiology is the VitMode editorial team responsible for: sleep, circadian rhythm, cognition and recovery. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

54 publications

VM

Redakcja VitMode — Serce i układ krążenia

Editorial team

VitMode Editorial — Heart and Circulation is the VitMode editorial team responsible for: the heart, blood pressure, lipids and cardiovascular prevention. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

56 publications

VM

Redakcja VitMode — Zdrowie psychiczne

Editorial team

VitMode Editorial — Mental Health is the VitMode editorial team responsible for: mental health, stress, mood and their link with sleep. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

29 publications

VM

Redakcja VitMode — Odporność, infekcje i skóra

Editorial team

VitMode Editorial — Immunity, Infections and Skin is the VitMode editorial team responsible for: immunity, recurrent infections and the health of skin and mucous membranes. The team has no individual bylines — texts are prepared by VitMode editors from primary sources (clinical trials, meta-analyses, guidelines). Every cited PubMed paper is automatically checked for a matching identifier, title and publication year. The content is educational and does not replace medical advice. Factual errors can be reported in a comment under the post or through the contact form; corrections are made by the editorial team.

0 publications

Did you know?

Skeletal muscle stores roughly 95% of the body's total creatine — the brain and testes use the remaining 5%.

Blood vitamin D levels can vary up to 10-fold between people living at the same latitude.

Caffeine and L-theanine in a 2:1 ratio is one of the best-studied nootropic combinations — both compounds occur naturally together in tea leaves.

FAQ

Frequently asked questions

No. Our content is educational and summarizes the available scientific literature. It doesn't replace a consultation with a doctor, pharmacist or dietitian — always discuss supplementation and lifestyle changes with a specialist, especially if you have an existing condition or take medication.

Every entry in the knowledge base references specific scientific studies (with links to the sources), and content is prepared by the VitMode editorial team from primary sources. Cited PubMed records are verified automatically against the NCBI database (identifier, title, year).

Every entry carries a label: 'strong evidence' (numerous clinical trials, meta-analyses), 'moderate' (promising but limited studies), 'early-stage' (mostly animal studies or small pilot trials), or 'hypothesis' (a plausible mechanism, but poorly studied clinically).

Yes — every knowledge base page has a comments section, and factual errors can be reported directly to our editorial team. Verifying submissions is part of our editorial process.