Medications
Mechanisms, interactions and contexts of use for common medications — for educational purposes only, not a recommendation.
4.5Metformin
The most commonly prescribed drug for type 2 diabetes in the world — with a well-understood metabolic mechanism and an intensively studied, but still unproven, potential to slow aging.
4.4Statins
The best-researched class of LDL-cholesterol-lowering drugs, with one of the largest evidence bases in all of cardiology — yet still surrounded by numerous, largely unfounded fears.
4.3Proton Pump Inhibitors (PPIs)
Among the most commonly prescribed drugs in the world, effectively suppressing stomach acid production — but increasingly used chronically for longer than clinical guidelines suggest.
4.5Tirzepatide
The first approved drug that simultaneously activates two different incretin receptors — GIP and GLP-1 — rather than just one, like older drugs in this class. In head-to-head trials it produced greater weight loss than semaglutide, at the cost of a very similar side-effect profile.
4.5Minoxidil
A drug that was supposed to treat high blood pressure and instead became the longest-running over-the-counter hair-loss treatment in the world — discovered by accident, working through a completely different mechanism than finasteride, with one of the longest clinical-trial track records in dermatology.