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CategoryBiohackingBiohacking
Evidence strengthResearch hypothesisModerate evidence
Evidence Score1/53/5
User rating2.8 (41)4.4 (79)
Typical doseNo approved, safe dosing guidelines exist for humans. Protocols found on internet forums (around 0.25–1 mg per injection, several times weekly, until visible tanning) are anecdotal practices never verified by any long-term safety clinical trial.—
FormIn online commerce: lyophilized powder for subcutaneous injection or nasal spray — with no standardization of purity or concentration between vendors—
Average priceok. 100–250 zł za fiolkę w nieregulowanej sprzedaży internetowej—
Monthly costok. 200–500 zł/miesiąc przy typowych protokołach stosowanych przez użytkowników forów—
Time to effectsDose-dependent skin darkening was described in the Phase I pilot study after several days to weeks of regular injections — but this is not information about safe use, only a description of a pharmacological effect noted in a very small study (3 people) of a substance never registered for this purpose.Not applicable — HRV is a monitoring indicator, not an intervention; changes in the trend become visible after several days to weeks of observation.
Who it's forFrom an editorial standpoint: no group has been identified for whom Melanotan II use can be honestly recommended given current evidence and the lack of market regulationAthletes wanting to objectively monitor training load and recovery