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CategoryTRTTRT
Evidence strengthStrong evidenceModerate evidence
Evidence Score4/53/5
User rating4.4 (87)4.7 (58)
Typical doseInjections: usually 50–100 mg weekly or 100–200 mg every 2 weeks (cypionate/enanthate ester); gels: dose set individually based on blood test resultsThere's no single universal dose — it's chosen individually to achieve a testosterone concentration in the mid-to-upper reference range for healthy young men
FormIntramuscular/subcutaneous injections, transdermal gels and creams, less often patchesIntramuscular/subcutaneous injections (every 1–2 weeks), transdermal gels and creams (daily), less commonly patches or subcutaneous implants
Average price
Monthly cost
Time to effectsBlood hormone levels stabilize after several weeks of starting therapy, regardless of form; subjective improvement in energy and libido usually appears within 3–6 weeks.Libido and sexual function: 3–6 weeks. Muscle mass and strength: 3–6 months with concurrent training. Bone density: 12+ months. Mood, energy, and cognitive function: inconsistent effect, practically indistinguishable from placebo in many patients.
Who it's forMen with confirmed hypogonadism qualifying for TRT under the supervision of an endocrinologist or andrologistMen with at least two confirmed, morning testosterone results below the laboratory reference range