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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
Add to comparison (2/4)
| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Strong evidence |
| Evidence Score | 3/5 | 5/5 |
| User rating | 4.7 (58) | 4.7 (52) |
| Typical dose | There's no single universal dose — it's chosen individually to achieve a testosterone concentration in the mid-to-upper reference range for healthy young men | Not applicable — this piece describes the full diagnostic pathway preceding TRT, not a drug dosing schedule |
| Form | Intramuscular/subcutaneous injections (every 1–2 weeks), transdermal gels and creams (daily), less commonly patches or subcutaneous implants | Blood tests: total testosterone (2x morning), free testosterone, SHBG, LH, FSH, prolactin, estradiol, complete blood count with hematocrit, PSA, lipid panel, fasting glucose or HbA1c, liver function tests, TSH; plus a digital rectal exam and an ADAM/AMS symptom questionnaire |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Libido and sexual function: 3–6 weeks. Muscle mass and strength: 3–6 months with concurrent training. Bone density: 12+ months. Mood, energy, and cognitive function: inconsistent effect, practically indistinguishable from placebo in many patients. | Not applicable — a diagnostic pathway preceding any possible start of therapy, usually taking several weeks. |
| Who it's for | Men with at least two confirmed, morning testosterone results below the laboratory reference range | Men with symptoms suggesting testosterone deficiency (reduced libido, erectile dysfunction, chronic fatigue, loss of muscle mass) considering TRT |