Tool
Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
Add to comparison (2/4)
| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Strong evidence |
| Evidence Score | 3/5 | 5/5 |
| User rating | 4.6 (57) | 4.7 (52) |
| Typical dose | Not applicable — this piece describes a hormonal mechanism accompanying TRT, not a dosing regimen for a specific drug | Not applicable — this piece describes the full diagnostic pathway preceding TRT, not a drug dosing schedule |
| Form | Assessment: blood estradiol, ideally by a high-sensitivity method (LC-MS/MS) rather than a standard immunoassay originally designed for women | Blood tests: total testosterone (2x morning), free testosterone, SHBG, LH, FSH, prolactin, estradiol, complete blood count with hematocrit, PSA, lipid panel, fasting glucose or HbA1c, liver function tests, TSH; plus a digital rectal exam and an ADAM/AMS symptom questionnaire |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Not applicable in a therapeutic sense — this describes a phenomenon that accompanies TRT, not an intervention. Estradiol usually stabilizes at a new level 4–8 weeks after the target, stable testosterone dose is established. | Not applicable — a diagnostic pathway preceding any possible start of therapy, usually taking several weeks. |
| Who it's for | Men starting testosterone therapy who are concerned about rising estradiol in their test results | Men with symptoms suggesting testosterone deficiency (reduced libido, erectile dysfunction, chronic fatigue, loss of muscle mass) considering TRT |