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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
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| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Moderate evidence |
| Evidence Score | 3/5 | 3/5 |
| User rating | 4.7 (176) | 4.7 (58) |
| Typical dose | In typical clinical practice, cypionate doses usually fall in the range of 50-100mg weekly, given intramuscularly or subcutaneously — these are ranges used in practice and clinical comparisons (e.g., Choi et al. 2022 used 100mg weekly), not a recommendation for self-directed use. It's worth noting that the population study by Bi and colleagues (2018) used substantially higher research doses (100-500mg weekly) solely for pharmacological modeling purposes, not as a model for typical replacement therapy. | There's no single universal dose — it's chosen individually to achieve a testosterone concentration in the mid-to-upper reference range for healthy young men |
| Form | Oil solution for intramuscular or subcutaneous injection | Intramuscular/subcutaneous injections (every 1–2 weeks), transdermal gels and creams (daily), less commonly patches or subcutaneous implants |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Subjective improvement in energy and libido may become noticeable within the first 3-6 weeks of therapy, but full stabilization of hormone concentrations and a reliable assessment of therapeutic effect, including the impact of route of administration on estradiol and hematocrit, usually takes 8-12 weeks of regular injections and follow-up blood tests. | Libido and sexual function: 3–6 weeks. Muscle mass and strength: 3–6 months with concurrent training. Bone density: 12+ months. Mood, energy, and cognitive function: inconsistent effect, practically indistinguishable from placebo in many patients. |
| Who it's for | Men with laboratory-confirmed hypogonadism starting testosterone replacement therapy | Men with at least two confirmed, morning testosterone results below the laboratory reference range |