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Supplement comparison tool

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CategoryTRTTRT
Evidence strengthModerate evidenceStrong evidence
Evidence Score4/55/5
User rating4.6 (61)4.7 (102)
Typical doseTotal testosterone + SHBG as the baseline test when altered SHBG is suspected of influencing the picture; free testosterone calculated via the Vermeulen formula from these two values (and albumin) — no separate blood draw neededNot applicable — this entry describes a safety protocol, not therapy dosing
FormDirect measurement by equilibrium dialysis — only at reference labs, for borderline cases or questionable calculated resultsMonitoring: complete blood count with hematocrit every 3–6 months in the first year, PSA and digital rectal exam before starting and periodically thereafter, lipid panel once a year
Average price
Monthly cost
Time to effectsNot applicable — this piece is reference and diagnostic in nature, not a description of an intervention.Not applicable — monitoring is an ongoing process that continues throughout the entire course of therapy.
Who it's forMen with a borderline or low-normal total testosterone result whose physician is considering an additional SHBG or free T testAll patients starting or continuing TRT