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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
Add to comparison (2/4)
| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Moderate evidence |
| Evidence Score | 4/5 | 3/5 |
| User rating | 4.6 (61) | 4.7 (58) |
| Typical dose | Total testosterone + SHBG as the baseline test when altered SHBG is suspected of influencing the picture; free testosterone calculated via the Vermeulen formula from these two values (and albumin) — no separate blood draw needed | There's no single universal dose — it's chosen individually to achieve a testosterone concentration in the mid-to-upper reference range for healthy young men |
| Form | Direct measurement by equilibrium dialysis — only at reference labs, for borderline cases or questionable calculated results | Intramuscular/subcutaneous injections (every 1–2 weeks), transdermal gels and creams (daily), less commonly patches or subcutaneous implants |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Not applicable — this piece is reference and diagnostic in nature, not a description of an intervention. | Libido and sexual function: 3–6 weeks. Muscle mass and strength: 3–6 months with concurrent training. Bone density: 12+ months. Mood, energy, and cognitive function: inconsistent effect, practically indistinguishable from placebo in many patients. |
| Who it's for | Men with a borderline or low-normal total testosterone result whose physician is considering an additional SHBG or free T test | Men with at least two confirmed, morning testosterone results below the laboratory reference range |