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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
Add to comparison (2/4)
| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Strong evidence |
| Evidence Score | 4/5 | 5/5 |
| User rating | 4.6 (61) | 4.7 (52) |
| Typical dose | Total testosterone + SHBG as the baseline test when altered SHBG is suspected of influencing the picture; free testosterone calculated via the Vermeulen formula from these two values (and albumin) — no separate blood draw needed | Not applicable — this piece describes the full diagnostic pathway preceding TRT, not a drug dosing schedule |
| Form | Direct measurement by equilibrium dialysis — only at reference labs, for borderline cases or questionable calculated results | Blood tests: total testosterone (2x morning), free testosterone, SHBG, LH, FSH, prolactin, estradiol, complete blood count with hematocrit, PSA, lipid panel, fasting glucose or HbA1c, liver function tests, TSH; plus a digital rectal exam and an ADAM/AMS symptom questionnaire |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Not applicable — this piece is reference and diagnostic in nature, not a description of an intervention. | Not applicable — a diagnostic pathway preceding any possible start of therapy, usually taking several weeks. |
| Who it's for | Men with a borderline or low-normal total testosterone result whose physician is considering an additional SHBG or free T test | Men with symptoms suggesting testosterone deficiency (reduced libido, erectile dysfunction, chronic fatigue, loss of muscle mass) considering TRT |