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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
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| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Moderate evidence |
| Evidence Score | 4/5 | 3/5 |
| User rating | 4.6 (52) | 4.7 (58) |
| Typical dose | SHBG is measured once from a venous blood sample, ideally together with total testosterone drawn in the morning (7:00–10:00), in the same draw | There's no single universal dose — it's chosen individually to achieve a testosterone concentration in the mid-to-upper reference range for healthy young men |
| Form | Blood test: SHBG + total testosterone; for a borderline result, it's worth adding albumin to calculate free testosterone (Vermeulen formula) or ordering a direct free testosterone measurement by equilibrium dialysis | Intramuscular/subcutaneous injections (every 1–2 weeks), transdermal gels and creams (daily), less commonly patches or subcutaneous implants |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Not applicable — this piece concerns interpreting a test result, not a therapeutic intervention. | Libido and sexual function: 3–6 weeks. Muscle mass and strength: 3–6 months with concurrent training. Bone density: 12+ months. Mood, energy, and cognitive function: inconsistent effect, practically indistinguishable from placebo in many patients. |
| Who it's for | People with a borderline or ambiguous total testosterone result | Men with at least two confirmed, morning testosterone results below the laboratory reference range |