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Supplement comparison tool
Pick up to 4 knowledge base entries and compare their dosage, price, evidence strength and ratings side by side — you can save or share a link to your selection.
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| Category | TRT | TRT |
| Evidence strength | Moderate evidence | Strong evidence |
| Evidence Score | 4/5 | 5/5 |
| User rating | 4.6 (52) | 4.7 (52) |
| Typical dose | SHBG is measured once from a venous blood sample, ideally together with total testosterone drawn in the morning (7:00–10:00), in the same draw | Not applicable — this piece describes the full diagnostic pathway preceding TRT, not a drug dosing schedule |
| Form | Blood test: SHBG + total testosterone; for a borderline result, it's worth adding albumin to calculate free testosterone (Vermeulen formula) or ordering a direct free testosterone measurement by equilibrium dialysis | Blood tests: total testosterone (2x morning), free testosterone, SHBG, LH, FSH, prolactin, estradiol, complete blood count with hematocrit, PSA, lipid panel, fasting glucose or HbA1c, liver function tests, TSH; plus a digital rectal exam and an ADAM/AMS symptom questionnaire |
| Average price | — | — |
| Monthly cost | — | — |
| Time to effects | Not applicable — this piece concerns interpreting a test result, not a therapeutic intervention. | Not applicable — a diagnostic pathway preceding any possible start of therapy, usually taking several weeks. |
| Who it's for | People with a borderline or ambiguous total testosterone result | Men with symptoms suggesting testosterone deficiency (reduced libido, erectile dysfunction, chronic fatigue, loss of muscle mass) considering TRT |