Blog
News, research and guides
755 articles from the VitMode editorial team.
Blog
755 articles from the VitMode editorial team.
GuidesFloaters (vitreous opacities) and flashes of light in the eye are most often the result of the natural ageing of the vitreous and its separation from the retina, but in some people they accompany a retinal tear that needs treatment. We describe where floaters come from, how often a vitreous detachment is accompanied by a retinal tear (according to systematic reviews and clinical series), which symptoms raise the risk many times over, what the examination looks like, when to go the same day and when a check-up after a few weeks is enough, and whether the floaters themselves ever need treatment.
October 24, 2026
GuidesPresbyopia, or age-related farsightedness, is the natural, progressive worsening of near vision that affects practically everyone who reaches middle age. We explain why the lens loses its ability to accommodate, how to recognise presbyopia and tell it apart from other causes, what the real correction options are (glasses, contact lenses, procedures), what is known about pilocarpine eye drops (results of randomised trials and meta-analyses and the status in the USA) and why there is no convincing evidence for supplements and eye exercises.
October 24, 2026
GuidesA stye (hordeolum) is an acute, painful inflammation of a gland at the edge of the eyelid, usually bacterial, whereas a chalazion is a chronic, usually painless lump that forms after a sebaceous gland of the eyelid becomes blocked. We explain how to tell them apart, what studies say about warm compresses, antibiotics, steroid injections and incision, why many lesions disappear without a procedure, when to see an ophthalmologist and how to reduce recurrences, including the role of eyelid margin inflammation. We also give the warning signs for which you must not wait.
October 24, 2026
GuidesLight sensitivity (photophobia) is an abnormal intolerance of light, not a disease in itself: it most often accompanies migraine, blepharospasm, head injury, dry eye and corneal disease, more rarely inflammation of the uvea, and in some cases it is a sign of an emergency such as meningitis. We explain how light causes pain (retinal-trigeminal pathways), how to distinguish benign from dangerous causes, what studies say about FL-41 tinted lenses and why dark glasses worn around the clock may not be a good idea.
October 24, 2026
GuidesMany lifters still cut rest to a minute, believing the “pump” and a hormone surge will give bigger gains. Randomized trials and systematic reviews say otherwise: for both strength and muscle mass, rests longer than a minute usually work somewhat better, and beyond roughly 90 seconds to 2 minutes extra rest stops helping clearly. We explain why, when shorter rests make sense, and how to build rest into a real programme.
October 24, 2026
Guides“No failure, no gain” is one of the most durable beliefs in the gym. Meta-analyses from recent years show a more complex picture: there is no evidence that a set taken to complete muscular failure beats one stopped 1–3 reps earlier, yet staying far from failure appears to blunt the stimulus. We explain what RIR is, what studies say about proximity to failure, how hard it is to judge your own reserve, and which exercises suit a final set taken “to the limit”.
October 24, 2026
GuidesFor decades we were told muscle is built in the 8–12 rep range and heavy sets are “just for strength”. Meta-analyses and studies in trained men show that when sets are taken close to failure, muscle growth is similar regardless of load, while maximal strength clearly improves more with high loads. We explain what this means in practice, what light sets “to failure” really cost and how to match rep range to your goal.
October 24, 2026
GuidesMust every muscle be trained at least twice a week, or is once enough, as in a classic “split”? Earlier reviews suggested an advantage of two sessions, but a newer meta-analysis of 25 studies shows that with the same number of sets per week, frequency has no significant effect on muscle growth. We explain what follows for your training plan, when higher frequency helps in practice and how to pick a layout for the days you have available.
October 24, 2026
GuidesA deload, a week of lighter training every few weeks, is almost a given in the gym. Yet the evidence is surprisingly thin: the only randomized trial in trained people found that a full week off in the middle of a 9-week programme did not increase muscle growth and even reduced strength gains. We explain what expert consensus says, what athletes actually do, how to tell it is worth reducing load, and how to run a deload sensibly if you decide on one.
October 24, 2026
GuidesThe best-studied way to measure blood pressure at home is twice a day, morning and evening, taking two readings about a minute apart each time, for seven consecutive days. In a large Finnish study (2,081 people, 6.8 years of follow-up) this kind of average predicted heart attacks and strokes better than single clinic readings. We explain why the number of readings matters more than the exact hour, how to prepare, and what to write down for your doctor.
October 24, 2026
GuidesAn upper-arm monitor is the default choice for home measurement because it produces fewer errors caused by body position. A wrist device can be accurate, but only if it has been clinically validated and your wrist is exactly at heart level during the measurement. We explain where the differences in readings come from, when a wrist monitor is a sensible option, how to check whether a specific model has been validated, and why cuff size is often more important than the measurement site itself.
October 24, 2026
GuidesA small difference in blood pressure between the right and left arm is common and usually reflects natural variability and measurement error. Only a systolic difference of at least 10, and especially 15 mmHg, that repeats across measurements is linked in studies with vascular disease: narrowing of the subclavian artery, peripheral artery disease and higher cardiovascular mortality. We explain the thresholds doctors use, how to measure the difference correctly at home, which arm to keep using, and when vascular imaging is needed.
October 24, 2026
GuidesIsolated systolic hypertension is a situation in which the top number is at least 140 mmHg while the bottom number stays below 90 mmHg. In people over 60 it is the most common form of hypertension and results mainly from stiffening of the arteries; in this group two large randomized trials (SHEP, Syst-Eur) showed that treatment reduces stroke risk by about 36-42%. In young adults, especially tall men, the picture is more complex: some cases are spurious, but cohort data show a higher cardiovascular risk. We explain the causes, the significance and the next steps.
October 24, 2026
GuidesA non-dipper is a person whose blood pressure falls by less than 10% at night compared with the day. This profile can be linked with higher cardiovascular risk, but it is also very unstable: in studies a repeat measurement often gives a different result, and the effect of medication timing on cardiovascular events, after the conflicting results of the Hygia and TIME trials, has not been confirmed. We explain how non-dipping is diagnosed, what causes it (including sleep apnoea and chronic kidney disease) and what to do about it.
October 24, 2026
GuidesA fasting glucose between 100 and 125 mg/dl (5.6–6.9 mmol/l) is called impaired fasting glucose (IFG) — an intermediate state between normal and diabetes, not a diagnosis of disease. The thresholds differ between the ADA (100 mg/dl) and the WHO (110 mg/dl), a single measurement can be affected by biological variability and pre-analytical error, and the risk of diabetes over the following years depends on which other abnormalities are present. We explain how to confirm the result, which tests to order second, and what the data say about the pace of progression.
October 22, 2026
GuidesThe dawn phenomenon is a physiological rise in glucose in the early morning hours, driven by the pre-dawn surge of cortisol and growth hormone, which reduces tissue sensitivity to insulin and increases glucose production in the liver. In healthy people it is usually small and invisible in test results; in people with type 2 diabetes it can be larger and add to a high fasting glucose. We explain how it differs from the Somogyi effect, what continuous glucose monitoring data show in people without diabetes, and how to interpret a high morning reading sensibly.
October 22, 2026
GuidesShaky hands, sweating, a racing heart and a 'crash' after a sweet meal are, for many people, proof of reactive hypoglycemia. Yet in studies, most people who make this diagnosis themselves do not actually have a low glucose at the time of symptoms. True postprandial hypoglycemia in people without diabetes is rare and requires documentation of Whipple's triad: symptoms, a low measured glucose, and relief of symptoms after glucose is raised. We explain why the glucose tolerance test is not used for this diagnosis, how easy it is to overread CGM data, and what the real causes are, from a postprandial syndrome to bariatric surgery.
October 22, 2026
GuidesNormal fasting glucose but an HbA1c in the prediabetes range — or the other way round? It is one of the most common puzzles in test results, and it usually does not mean the laboratory made a mistake. The two tests measure different things (a single morning measurement versus a 2–3 month average that depends on the lifespan of red blood cells), and HbA1c is influenced by iron deficiency, vitamin B12 deficiency, hemoglobin variants, kidney disease and an individual rate of glycation. We explain where discrepancies come from, which result to believe when, how fructosamine and the CGM-derived GMI work, and what a safe order of further tests looks like.
October 22, 2026
GuidesHOMA-IR is a simple index of insulin resistance calculated from fasting glucose and insulin: glucose (mg/dl) × insulin (µIU/ml) / 405, or glucose (mmol/l) × insulin (µIU/ml) / 22.5. The result is useful, but there is no single universal normal cut-off: thresholds differ between populations, sex, age and insulin assay methods, and a single measurement can carry a large error. We show the formula step by step with examples, explain the limitations compared with the euglycemic clamp and other indices, and what studies say about the link between a high HOMA-IR and diabetes, hypertension and cardiovascular events.
October 22, 2026
GuidesA GGT result above the reference range makes most people think of alcohol — yet it is one of the most sensitive and least specific enzymes in the whole liver panel. It is raised by drugs that induce liver enzymes, fatty liver linked to insulin resistance, impaired bile flow, and even excess body weight on its own. We explain what GGT actually measures, how to tell liver causes from non-liver ones, what the data linking GGT to cardiovascular risk really show, and which tests make sense when GGT is high but ALT and AST are normal.
October 22, 2026
GuidesA bilirubin result several times above the reference range with normal ALT, AST and GGT is the classic picture of Gilbert syndrome — the most common inherited disorder of bilirubin metabolism, which by various estimates affects a few to over ten percent of the population. It is usually not a liver disease and needs no treatment, yet it can cause anxiety, unnecessary tests and, sometimes, real problems — for example with the dosing of certain cancer drugs. We explain what the UGT1A1 variant is, what makes bilirubin fluctuate, how a doctor tells Gilbert syndrome from haemolysis and liver disease, what we do and do not know about its supposed protective effect on the heart, and when another cause must be sought.
October 22, 2026
GuidesWhen AST is higher than ALT on a liver panel, many people at once assume alcohol or cirrhosis. The AST-to-ALT ratio (the De Ritis ratio), however, is a clue and not a diagnosis: a reversed ratio can come from alcohol-related liver injury, but also from advanced fibrosis, muscle damage, haemolysis of the sample, or a rare, benign phenomenon called macro-AST. We explain where the difference between the two enzymes comes from, what the classic clinical studies say about it, how to tell a liver source from a muscle source, and which tests are worth doing when AST is higher than ALT.
October 22, 2026
GuidesAlkaline phosphatase (ALP) above the reference range is one of the commonest unexpected findings in blood tests and one of the hardest to interpret unambiguously. The enzyme comes mainly from two sources — the liver with the bile ducts, and bone — and it also rises physiologically in children, adolescents and pregnancy. We explain how to tell a liver source from a bone source with GGT and isoenzymes, which diseases most often lie behind a raised ALP, when the rise is transient and harmless, what studies say about an isolated raised ALP, and which tests to do as next steps.
October 22, 2026
GuidesLiver fibrosis, the scarring that develops in the organ after long-term injury, gives no symptoms for a long time — and it, not steatosis itself, determines the risk of cirrhosis. A biopsy is no longer needed for a first assessment: age, two liver enzymes and the platelet count are enough to calculate the FIB-4 index. We explain the formula, the 1.3 and 2.67 cut-offs, why the result must be read differently in young people and after age 65, how FIB-4 combines with the ELF test and elastography in two-step pathways, what its limitations are (including in people with diabetes) and when to be referred to a hepatologist.
October 22, 2026